Historically, the word pain is a Middle English term, derived from Old French peine, from Latin poena, penalty, pain, from Greek poin, penalty, and is defined as: 1)An unpleasant sensation occurring in varying degrees of severity as a consequence of injury, disease, or emotional disorder; 2)Suffering or distress; 3)Pains-The pangs of childbirth; 4)Pains-Great care or effort: take pains with one's work; 5)Informal. A source of annoyance; a nuisance (Reference: Dictionary.com). The diagnosis and treatment of pain is one of the most important concerns of patients, and medicine has made major advances in recent years with novel therapies to treat this age-old problem.

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